Long-term Drug Therapy and Drug Holidays for Osteoporosis Fracture Prevention: A Systematic Review
https://annals.org/aim/fullarticle/2731605/long-term-drug-therapy-drug-d...
Fink, Howard A. MacDonald, Roderick Forte, Mary L. Rosebush, Christina E. Ensrud, Kristine E. Schousboe, John T. Nelson, Victoria A. Ullman, Kristen Butler, Mary Olson, Carin M. Taylor, Brent C. Brasure, Michelle Wilt, Timothy J.
2019
Long-term alendronate and zoledronic acid therapies reduce fracture risk in women with osteoporosis. Long-term bisphosphonate treatment may increase risk for rare adverse events, and continuing treatment beyond 3 to 5 years may reduce risk for vertebral fractures. Long-term hormone therapy reduces hip fracture risks but has serious harms. PMID: 31009947
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