Long-term Drug Therapy and Drug Holidays for Osteoporosis Fracture Prevention: A Systematic Review
Fink, Howard A.MacDonald, RoderickForte, Mary L.Rosebush, Christina E.Ensrud, Kristine E.Schousboe, John T.Nelson, Victoria A.Ullman, KristenButler, MaryOlson, Carin M.Taylor, Brent C.Brasure, MichelleWilt, Timothy J.
Long-term alendronate and zoledronic acid therapies reduce fracture risk in women with osteoporosis. Long-term bisphosphonate treatment may increase risk for rare adverse events, and continuing treatment beyond 3 to 5 years may reduce risk for vertebral fractures. Long-term hormone therapy reduces hip fracture risks but has serious harms.
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American College of Physicians