Suppression of gyrase-mediated resistance by C7 aryl fluoroquinolones
Nucleic Acids Research
Malik, MMustaev, ASchwanz, HALuan, GShah, NOppegard, LMde Souza, ECHiasa, HZhao, XKerns, RJMalik, MDrlica, K
Addition of ciprofloxacin (Cip-DNP) reduced protection due to resistance substitutions in Escherichia coli GyrA
helix-4, consistent with the existence of a second drug-binding mode not evident in X-ray structures of
DNA Topoisomerase IVDNA GyraseFluoroquinolones
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