Suppression of gyrase-mediated resistance by C7 aryl fluoroquinolones

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Title: Suppression of gyrase-mediated resistance by C7 aryl fluoroquinolones
URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4838383/pdf/gkw161.pdf
Journal Title: Nucleic Acids Research
Author: Malik, M
Mustaev, A
Schwanz, HA
Luan, G
Shah, N
Oppegard, LM
de Souza, EC
Hiasa, H
Zhao, X
Kerns, RJ
Malik, M
Drlica, K
Date: 2016
Description: Addition of ciprofloxacin (Cip-DNP) reduced protection due to resistance substitutions in Escherichia coli GyrA
helix-4, consistent with the existence of a second drug-binding mode not evident in X-ray structures of
drug-topoisomerase-DNA complexes.
Subject: Faculty scholarship
Form: Publication
Format: Text/pdf
Type: Text
Volume: 44
Issue number: 7
Start page: 3304
End page: 3316
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