During a survey of actinobacteria known to suppress the growth of Streptomyces scabies (the causative agent of potato scab disease) in vivo, six new rhamnosylated alkaloids, the solphenazines A–F (1–6), were isolated from a biological control strain of Streptomyces (DL-93). The known rhamnosyl analogue of paraben (9) was also isolated along with a new rhamnosylated derivative of N-methyl-p-aminobenzoic acid (10). None of the compounds exhibited any antibacterial or antifungal activity against a standard panel of microorganisms, but compounds 1, 2, and 6 displayed some cytotoxicity against HCT-116 cancer cells. Additional in vitro testing provided data suggesting that the cytotoxic activity is not due to DNA intercalation or topoisomerase inhibition.
Journal Title
Volume Number
76
Issue Number
1
Collection name
Creator Affiliated Organization
Description
Article co-written by Northwestern Health Sciences University faculty member Lisa Oppegard. The article was published in the Journal of Natural Products in 2013. Citation: J. Nat. Prod. 2013, 76, 91-96.
Abstract
Publisher
Date Published
2013
Local Subject
Resource Type
File Type
Genre
Copyright Date
2013
Contact Information
Northwestern Health Sciences University, 2501 West 84th Street, Bloomington, MN 55431. https://www.nwhealth.edu/library/
Copyright
Rights Holder
ACS Publications