Journal Title
Volume Number
54
Issue Number
5
Collection name
Creator Affiliated Organization
Description
Article co-written by Northwestern Health Sciences University faculty members John Pirog, Kashif Ahmad, and Yongping Jiang. The article was published in Molecular Carcinogenesis in May 2015, Volume 54, Issue 5, pages 368-378. The article was first published on November 19, 2013.
Abstract

The herbs Scutellaria baicalensis (SB) and Fritillaria cirrhosa (FC) are widely used in Chinese medicine to treat several aliments and as an adjuvant to chemotherapy of lung cancer. No information is available regarding the two herbs' influence on ovarian and endometrial cancer. To fill this data gap we compared cell growth responses to SB and FC in ovarian and endometrial cancer cell lines. Dose-dependent cell growth inhibition was observed following higher doses in all cell lines while lower doses stimulated growth in only endometrial cell lines. Higher doses of SB and FC significantly decreased cell growth on soft agar and decreased the invasive potential of cancer cells. Treatment of cells with both herbs resulted in activation of caspase-3, G0/G1 phase cell cycle arrest, downregulation of cyclins D1 and D3 and induction of p27. Both herbs decreased NFκB DNA binding, reduced expression of phosphorylated IκBα, abrogated NFκB activation, and downregulated NFκB-regulated metastasis-promoting proteins in cancer cells. Furthermore, knockdown of NFκB attenuated SB- and FC-induced cell growth inhibition. These results suggest that inhibition of NFκB activation may be an important mechanism for growth suppression by SB and FC. Data indicate that these herbs may represent a new source of agents for NFκB inhibition in cancer therapy. © 2013 Wiley Periodicals, Inc.

Date Published
2015
Resource Type
File Type
Genre
Contact Information
Northwestern Health Sciences University, 2501 West 84th Street, Bloomington, MN 55431. https://www.nwhealth.edu/library/
Rights Holder
Wiley